Pregabalin: Generic, Uses, Side Effects, Dosages, Interactions & Warnings
You may have a higher chance of swelling of your hands or feet or gaining weight if you are also taking Avandia (rosiglitazone), Avandamet (contains rosiglitazone and metformin), or Actos (pioglitazone). You may have a higher chance for dizziness and sleepiness if you take LYRICA or LYRICA CR with alcohol, narcotic pain medicines, or medicines for anxiety. You may have a higher chance of swelling of your hands or feet or gaining weight if you are also taking certain diabetes medicines. You may have a higher chance for dizziness and sleepiness if you take LYRICA with alcohol, narcotic pain medicines, or medicines for anxiety. Drugs used to treat seizures increase the risk of suicidal thoughts or behavior.
Safety and effectiveness in pediatric patients have not been established. In the prenatal-postnatal study in rats, pregabalin prolonged gestation and induced dystocia at exposures greater than or equal to 50 times the mean human exposure (AUC (0–24) of 123 μg•hr/mL) at the MRD. In standard preclinical in vivo lifetime carcinogenicity studies of LYRICA, an unexpectedly high incidence of hemangiosarcoma was identified in two different strains of mice [see Nonclinical Toxicology]. Clinical experience during LYRICA’s premarketing development provides no direct means to assess its potential for inducing tumors in humans. Inform patients that LYRICA-related dizziness and somnolence may impair their ability to perform tasks such as driving or operating machinery [see Patient Counseling Information].
These findings were observed at plasma pregabalin exposures (AUC) greater than or equal to 2 times those achieved in humans given the maximum recommended dose of 600 mg/day. Similar lesions were not observed in lifetime carcinogenicity studies in two strains of mice or in monkeys treated for 1 year. Based on animal studies, there is a potential risk of tumorigenicity with pregabalin exposure via breast milk to the breastfed infant [see Nonclinical Toxicology].
Spinal Cord Injury Nerve Pain
Following oral administration, pregabalin reaches peak plasma concentration at 0.5 hours to 2 hours in the fasted state. Both apparent clearance (CL/F) and apparent volume of distribution increase as body weight increases. The mean t½ is 3 to 4 hours in pediatric subjects up to 6 years of age, and 4 to 6 hours in those 7 years of age and older.
This medication is recommended not to be mixed with these other medications. More serious, yet less rare side effects include fast heartbeat, sores, ulcers, or white spots in the mouth or on the lips, difficulty with swallowing, etc. One study looked at adults taking one to three other antiepileptic drugs (AEDs) that were not effectively preventing partial onset seizures.
This ensures that you can tolerate the drug, and no changes need to be made to your dosage. The cost of Lyrica does not differ too drastically when comparing different dosages; however, there is a drastic difference in price when comparing forms. The cheapest option for 30 capsules of brand-name Lyrica is $266.38 at 50mg, 100mg, 150mg, 200mg, and 300mg doses. The expiration date helps guarantee that the medication is effective during this time. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications.
Is Lyrica a controlled substance?
The following figure displays responder rate by dose for two of the studies. Pregabalin clearance is nearly proportional to creatinine clearance (CLcr). Dosage reduction in patients with renal dysfunction is necessary.
- Both the efficacy and adverse event profiles of LYRICA have been shown to be dose-related.
- Pregabalin also affects chemicals in the brain that send pain signals across the nervous system.
- The insurance company will review the prior authorization request and decide if the drug will be covered.
- Patients treated with LYRICA 7 mg/kg/day did not show improvement relative to placebo.
For patients undergoing hemodialysis, adjust the pregabalin daily dose based on renal function. In addition to the daily dose adjustment, administer a supplemental dose immediately following buy pregabalin without a prescription every 4-hour hemodialysis treatment (see TABLE 2). Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use.
Call your doctor right away if you have an allergic reaction to Lyrica, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or you think you’re having a medical emergency. Most of these side effects may go away within a few days or a couple of weeks. If they become more severe or don’t go away, talk with your doctor or pharmacist.
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As a Mira member, you will be able to claim discounts for hundreds of prescriptions at pharmacies in your location. Within your member portal, click on the “Rx Discounts” tile; Enter the name, dosage, and quantity of your medication and choose your location. Pharmacies carrying your medication will populate with the lowest option shown first.